Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.Goedhart J, van Unen J. (2017) Small GTPases May 19:1-9.doi: 10.1080/21541248.2017.1302551
F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD. (2016) Nature Communications 7, 10493.doi: 10.1038/ncomms10493
Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella TW Jr, Goedhart J. (2016) Molecular Pharmacology 90, 162-76.doi: 10.1124/mol.116.104505
Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J. (2015) Scientific Reports 5, 14693.doi: 10.1038/srep14693
Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%.Goedhart, J., von Steten, D., Noirclerc-Savoye, M., Lelimousin, M., Joosen, L., Hink, M.A., van Weeren, L., Gadella, T.W., Jr., Royant, A. (2012) Nature Communications 3, 751.doi: 10.1038/ncomms1738
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